Category Archives: Diabetes News

Two-Step Screening Uncovers Heart Failure Risk in Diabetes

Diabetes News


TOPLINE:

A two-step screening, using a risk score and biomarkers, can identify patients with diabetes at a higher risk for heart failure who will most likely benefit from preventive drugs.

METHODOLOGY:

  • Researchers compared screening methods and downstream risk for heart failure in 5 years, particularly those without atherosclerotic cardiovascular disease (ASCVD).
  • They pooled data from 4889 patients (age ≥ 40 years, about half women) with diabetes, no heart failure at baseline, and no signs of ASCVD. All patients had undergone screening to determine their heart failure risk level.
  • Researchers assessed the heart failure risk for patients without ASCVD with one-step screening strategies:
  • They next assessed a sequential two-step strategy, using the second test only for those deemed low risk by the first, with a combination of two tests (WATCH-DM/NT-proBNP, NT-proBNP/hs-cTn, or NT-proBNP/echocardiography), the second used for those deemed low-risk by the first test.
  • The primary outcome was incident heart failure during the 5-year follow-up. The researchers also assessed the cost-effectiveness of screening and subsequent treatment of high-risk patients with a sodium-glucose cotransporter 2 inhibitor.

TAKEAWAY:

  • Overall, 301 (6.2%) heart failure events occurred among participants without ASCVD.
  • Of the heart failure events, 53%-71% occurred among participants deemed high risk by a one-step screening strategy, but 75%-89% occurred among patients assessed as high risk in two steps.
  • The risk for incident heart failure was 3.0- to 3.6-fold higher in the high- vs low-risk group identified using a two-step screening approach.
  • Among the two-step strategies, the WATCH-DM score first, followed by selective NT-proBNP testing for patients deemed low risk by the first test, was the most efficient, with the fewest tests and lowest screening cost.

IN PRACTICE:

“Matching effective but expensive preventive therapies to the highest-risk individuals who are most likely to benefit would be an efficient and cost-effective strategy for heart failure prevention,” the authors wrote.

SOURCE:

The study led by Kershaw Patel of the Houston Methodist Academic Institute, Houston, Texas, was published online in Circulation.

LIMITATIONS:

The study findings may not be generalized, as the study included older adults with a high burden of comorbidities. This study may have missed some individuals with diabetes by defining it with fasting plasma glucose, which was consistently available across cohort studies, instead of with the limited A1c data. Moreover, the screening strategies used did not consider other important prognostic factors, such as diabetes duration and socioeconomic status.

DISCLOSURES:

Two authors declared receiving research support from the National Heart, Lung, and Blood Institute. Several authors disclosed financial relationships with multiple pharmaceutical device and medical publishing companies in the form of receiving personal fees; serving in various capacities such as consultants, members of advisory boards, steering committees, or executive committees; and other ties.



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Kelly Clarkson’s weight loss came after she was diagnosed with pre-diabetes | Entertainment

Diabetes News


Kelly Clarkson decided to drop the pounds after being told she was pre-diabetic.

The 41-year-old singer was forced to explain her weight loss after it was rumoured she used weight-loss injections such as Ozempic, however, she has denied this to be the case, and revealed the health warning from her doctor was behind the shred.



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AI Boosts Diabetic Eye Screening and Follow-Up in Youth

Diabetes News


TOPLINE:

Artificial intelligence (AI) boosts the screening rate for potentially blinding diabetes eye disorders in a diabetes clinic compared with referral to an eye care provider (ECP) in a racially and ethnically diverse youth population with diabetes.

METHODOLOGY:

  • Although early screening and treatment can prevent diabetic eye diseases (DEDs), many people with diabetes in the United States lack access to and knowledge about diabetic eye exams.
  • The ACCESS trial included 164 patients aged 8-21 years (58% female, 35% Black, and 6% Hispanic) with type 1 or 2 diabetes with no known DED and no diabetic eye exam in the last 6 months.
  • In a diabetes clinic, patients were randomly assigned to an AI diabetic eye exam (intervention arm) then and there or to standard of care, referred to an ECP with scripted educational material (control).
  • Participants in the intervention arm underwent the 5- to 10-minute autonomous AI diabetic eye exam without pharmacologic dilation. The results were generated immediately as either “DED present” or “DED absent.”
  • The primary outcome was the completion rate of documented diabetic eye exams within 6 months (“primary gap closure rate”), either by AI or going to the ECP. The secondary outcome was ECP follow-up by intervention participants with DED (intervention) and all control patients.

TAKEAWAY:

  • Within 6 months, all the participants (100%) in the intervention arm completed their diabetic eye exam, a primary care gap closure rate of 100% (95% CI, 96%-100%).
  • The rate of primary care gap closure was significantly higher in the intervention vs control arm (100% vs 22%; P < .001).
  • In the intervention arm, 64% of patients with DED followed up with an eye care provider within 6 months compared with a mere 22% participants in the control arm (P < .001).
  • Participants reported high levels of satisfaction with autonomous AI, with 92.5% expressing satisfaction with the exam’s duration and 96% expressing satisfaction with the whole experience.

IN PRACTICE:

“Autonomous AI increases diabetic eye exam completion rates and closes this care gap in a racially and ethnically diverse population of youth with diabetes, compared to standard of care,” the authors wrote.

SOURCE:

This study, which was led by Risa M. Wolf, MD, Department of Pediatrics, Division of Endocrinology, Johns Hopkins School of Medicine, Baltimore, Maryland, was published online on January 11, 2024, in Nature Communications.

LIMITATIONS:

This study used autonomous AI in the youth although it’s not approved by the US Food and Drug Administration for use in individuals aged 21 years and younger. Some of the participants in this study were already familiar with autonomous AI diabetic eye exams, which might have contributed to their willingness to participate in the current study. The autonomous AI used in the study was shown to have a lack of racial and ethnic bias, but any AI bias caused by differences in retinal pigment has potential to increase rather than decrease health disparities.

DISCLOSURES:

The clinical trial was supported by the National Eye Institute of the National Institutes of Health and the Diabetes Research Connection. Wolf, the lead author, declared receiving research support from Boehringer Ingelheim and Novo Nordisk outside the submitted work. Co-author Michael D. Abramoff declared serving in various roles such as investor, director, and consultant for Digital Diagnostics Inc., as well as other ties with many sources.



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Global Diabetes Therapeutics and Diagnostics Set to Hit $132.0 Billion in 2028- Insights from BCC Research

Diabetes News


Latest Study Forecasts Global Diabetes Therapeutics and Diagnostics Market to Surge to $132 Billion by 2028, Growing at a 5.2% CAGR

BOSTON, Jan. 16, 2024 /PRNewswire/ — The global market for diabetes therapeutics and diagnostics is experiencing remarkable growth, poised to reach $132.0 billion by 2028. Fueled by increasing diabetes prevalence and technological advancements, this market is at the forefront of healthcare innovation. In this overview, we explore the key factors propelling its expansion, highlighting the intersection of research, pharmaceutical development, and diagnostic technologies shaping the landscape of diabetes management worldwide. Join us as we navigate the dynamic trends and impactful solutions driving the global markets for diabetes therapeutics and diagnostics.

“According to the latest research study, the demand for Global Markets for Diabetes Therapeutics and Diagnostics to increase from $102.2 billion in 2023 to reach $132.0 billion by 2028, at a compound annual growth rate (CAGR) of 5.2% from 2023 through 2028.”

This comprehensive report delves into the far-reaching implications of current trends within the diabetes therapeutics and diagnostics market, offering insights into the market’s size, growth trajectory, and its impact on both global and key national markets. A thorough exploration of pharmaceutical and medical industry players is provided, including profiles of industry leaders and updates on mergers and acquisitions. The report further includes a detailed discussion on competitive intelligence, innovative technologies, market dynamics, and regional opportunities. Notably, it furnishes five-year global sales forecasts for leading drug and device categories, complemented by country-level breakdowns. The analysis extends to major players’ recent developments and product portfolios, with a keen focus on patent analysis to highlight technological trends across the U.S., Europe, and Japan. The market analysis culminates in estimates of the compound annual growth rate (CAGR) for the diabetes therapeutics and diagnostics market. Geographically, the report segments the global market into North America, Europe, Asia-Pacific, and the Rest of the World, utilizing 2022 as the base year for market estimates, projecting through year-end 2028.

The Diabetes Delivery Devices segment has experienced exceptional growth, particularly fueled by technological advancements like implantable insulin delivery pumps and external insulin pumps. Notably, the integration of wireless technology and miniaturization in medical device components is anticipated to spur innovation in diabetes care devices, thereby propelling market growth throughout the forecast period. The adoption of cutting-edge technologies such as 3D printing, artificial intelligence, and big data analytics in device manufacturing is contributing to reduced operating costs and enhanced product quality. Within the Asia Pacific region, India stands out with the highest growth rate, propelled by supportive government policies, increased awareness about diabetes, and the presence of dedicated associations and societies for diabetes control and monitoring. This growth trajectory positions India as a key player in the region, potentially surpassing the pace observed in the U.S. and other nations in the Asia Pacific region.

Discover More: Dive into the Details of the Global Markets for Diabetes Therapeutics and Diagnostics Market’s Growth Trajectory and Future Prospects. Click Here to Learn More

Driving forces behind the global markets for diabetes therapeutics and diagnostics market’s insights growth comprises:

  1. Increasing incidence & prevalence of diabetes- The increasing incidence and prevalence of diabetes globally have become a significant public health concern. The World Health Organization (WHO) estimates that the number of people with diabetes has risen sharply over the past few decades, reaching an alarming prevalence. Factors such as sedentary lifestyles, unhealthy dietary habits, and rising obesity rates contribute to the surge in diabetes cases. The condition not only poses immediate health risks but also leads to long-term complications such as cardiovascular diseases, kidney failure, and blindness. The economic burden of diabetes on healthcare systems is substantial, emphasizing the urgent need for effective preventive measures, education, and accessible healthcare resources to address and manage this growing health crisis.
  2. Changing lifestyle habits- Changing lifestyle habits have emerged as a key factor influencing health outcomes worldwide. In recent decades, a shift towards sedentary routines, poor dietary choices, and increased stress levels has significantly impacted public health. Sedentary lifestyles, characterized by reduced physical activity, contribute to the rising incidence of health issues such as obesity, cardiovascular diseases, and diabetes. Unhealthy dietary habits, often marked by high consumption of processed foods and sugary beverages, further exacerbate these health concerns. The modern pace of life, with heightened work-related stress and irregular sleep patterns, also plays a role in compromising overall well-being. Recognizing the impact of lifestyle choices on health, there is a growing emphasis on promoting healthier habits through education, awareness campaigns, and policy interventions to foster positive changes in daily routines and improve long-term health outcomes.
  3. Growing geriatric population– The growing geriatric population represents a significant demographic shift with profound implications for healthcare systems worldwide. As advancements in healthcare contribute to increased life expectancy, the proportion of elderly individuals is on the rise. This aging demographic trend is associated with a higher prevalence of chronic conditions and age-related health issues, placing additional demands on healthcare infrastructure and resources. Conditions such as cardiovascular diseases, osteoporosis, and neurodegenerative disorders become more prevalent in older age groups, necessitating specialized and comprehensive healthcare services. Addressing the unique healthcare needs of the elderly, including preventive measures, specialized medical care, and social support systems, becomes crucial in ensuring a healthy and dignified aging process for this expanding segment of the population. The phenomenon of a growing geriatric population underscores the importance of proactive healthcare planning and strategies to meet the evolving needs of an aging society.
  4. Increase in prevalence of chronic diseases- The increase in the prevalence of chronic diseases represents a global health challenge, with far-reaching implications for individuals, healthcare systems, and economies. Chronic diseases, such as heart disease, diabetes, and respiratory conditions, have become more prevalent due to factors like aging populations, changing lifestyles, and environmental influences. These conditions often require long-term management and care, placing a substantial burden on healthcare resources. The rise in chronic diseases not only impacts the quality of life for affected individuals but also contributes significantly to healthcare costs. Prevention and early intervention strategies, along with lifestyle modifications, are crucial in mitigating the growing burden of chronic diseases. Addressing this trend requires a comprehensive and coordinated approach, involving public health initiatives, medical research, and innovative healthcare delivery models to promote healthier living and enhance the management of chronic conditions on a global scale.

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Report Synopsis        

Report Metrics

Details

Base year considered

2022

Forecast Period considered

2023-2028

Base year market size

$97.3 billion

Market Size Forecast

$132.0 billion

Growth Rate

CAGR of 5.2% for the forecast period of 2023-2028

Segment Covered

Product Group, End-User, and Region

Regions covered

North America, Europe, Asia-Pacific, and Rest of the World (RoW).

Countries covered

U.S., Canada, Mexico, France, Germany, U.K., Italy, Spain, China, India, and Japan

Key Market Drivers

•  Increasing incidence & prevalence of diabetes

•  Changing lifestyle habits

•  Growing geriatric population

•  Increase in prevalence of chronic diseases

The Rising Demand for Global Markets for Diabetes Therapeutics and Diagnostics:

The escalating demand for global markets in diabetes therapeutics and diagnostics is indicative of the increasing prevalence of diabetes and the imperative for advanced healthcare solutions. With the market projected to reach $132.0 billion by 2028, the surge is fueled by a combination of technological innovations, heightened awareness, and the continuous pursuit of more effective treatment and diagnostic options. The escalating demand is not only a testament to the growing burden of diabetes but also underscores the vital role of pharmaceutical advancements and diagnostic technologies in addressing this global health challenge. As countries grapple with rising diabetes rates, the demand for cutting-edge therapeutics and diagnostics is a driving force propelling this market’s growth, emphasizing the urgent need for comprehensive solutions to better manage and combat the diabetes epidemic on a worldwide scale.

Trends and Innovations:

The landscape of global markets for diabetes therapeutics and diagnostics is shaped by dynamic trends and ongoing innovations. Notably, the Diabetes Delivery Devices segment has witnessed remarkable growth, propelled by technological advancements like implantable insulin delivery pumps and external insulin pumps. The integration of wireless technology and miniaturization in medical device components is fostering innovation in diabetes care, while 3D printing, artificial intelligence, and big data analytics are driving manufacturing efficiency. Amidst these trends, India stands out in the Asia Pacific region with the highest growth rate, supported by government policies, heightened diabetes awareness, and dedicated associations. These trends underscore a transformative era in diabetes management, where technological advancements and strategic initiatives converge to address the evolving needs of patients and healthcare systems globally.

Challenges and Opportunities:

The global markets for diabetes therapeutics and diagnostics present a landscape of both challenges and opportunities. The increasing prevalence of diabetes poses a substantial challenge to healthcare systems globally, necessitating innovative and scalable solutions. Rising healthcare costs, coupled with the complexities of managing chronic conditions, contribute to the challenges faced by the industry. However, within these challenges lie significant opportunities for growth and improvement. Technological advancements offer the potential for more efficient and effective diabetes management, from innovative therapies to advanced diagnostic tools. Additionally, the growing awareness of diabetes and proactive government policies present opportunities for market expansion, especially in regions like India, where a higher growth rate is anticipated. Successfully navigating these challenges and leveraging the opportunities can lead to transformative breakthroughs in diabetes care, benefiting both patients and the broader healthcare ecosystem.

This report on the Global Markets for Diabetes Therapeutics and Diagnostics provides comprehensive insights and analysis, addressing the following key questions:

  1. What are the anticipated dimensions and expansion pace of the diabetes therapeutics and diagnostics market?

    The market is expected to witness an increase from $97.2 billion in 2022 to $132.0 billion by 2028, with a compound annual growth rate (CAGR) of 5.2% throughout the forecast period.

  2. What factors contribute to the growth of the diabetes therapeutics and diagnostics market? 

    The market is experiencing growth driven by the increasing incidence and prevalence of diabetes, advancements in technology related to diabetes treatment and diagnostics, and strategic initiatives undertaken by major players in developed nations.

  3. What divisions are included in the diabetes therapeutics and diagnostics market?

    The market is categorized based on product group, end-user, and region. 

  4. Which segment is projected to lead the market by the conclusion of 2028 in terms of product groups? 

    The Diabetes Therapeutics segment is anticipated to dominate the market by the end of 2028. 

  5. In the diabetes therapeutics and diagnostics market, which region commands the greatest market share?

    North America boasts the highest market share in this sector.

  6. Which companies or players are prominent in the diabetes therapeutics and diagnostics market? 

    Key players in the market encompass Novo Nordisk A/S, Lilly, Boehringer Ingelheim International GmbH, AstraZeneca, Abbott, Merck & Co., Inc., Sanofi, Dexcom, Inc., Medtronic, and others.

Some of the Key Market Players Are:

  • 77 ELEKTRONIKA KFT.
  • ABBOTT
  • ALTUCELL
  • ASCENSIA DIABETES CARE HOLDINGS AG.
  • ASTRAZENECA
  • B. BRAUN SE
  • BIOCON
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH
  • DANAHER
  • DEXCOM INC.
  • EMBECTA CORP.
  • INSULET CORPORATION.
  • JOHNSON & JOHNSON SERVICES INC.
  • LIFESCAN IP HOLDINGS LLC
  • LILLY
  • MEDTRONIC
  • MENARINI GROUP (A. MENARINI DIAGNOSTICS S.R.L)
  • MERCK & CO. INC.
  • MERCK KGAA
  • NEXTCELL PHARMA AB
  • NIPRO
  • NOVA BIOMEDICAL
  • NOVARTIS AG
  • NOVO NORDISK A/S
  • ROCHE (F. HOFFMANN-LA ROCHE LTD)
  • SANOFI
  • TAKEDA PHARMACEUTICAL COMPANY LIMITED.
  • TANDEM DIABETES CARE INC.
  • TERUMO CORPORATION
  • YPSOMED AG

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Automatic Hybrid Insulin Delivery Systems Help Manage T1D

Diabetes News


Advanced hybrid closed-loop (AHCL) systems improve glycemic control in patients with type 1 diabetes, according to a prospective evaluation by 16 diabetes specialists in Spain. The current hybrid closed-loop systems have gone one step further by mimicking the body’s natural insulin delivery systems. 

The objective of this evaluation was to analyze the results of two AHCLs currently on the market (MM780G with SmartGuard and Tandem t:slimX2 with Control-IQ) and to determine their real-life benefits, based on the information provided by the patients.

“The evaluation involved 150 patients from 14 centers, 75 for each system, and lasted for 3 months. An initial evaluation was carried out, and another was done at the end of the 3 months to determine diabetes control and user satisfaction. Glycosylated hemoglobin (HbA1c), time in different glycemic ranges, and patient-reported outcomes were assessed. To take quality of life into consideration, a 146-point questionnaire was completed to assess all aspects of the condition at a later stage,” Pilar Beato, MD, specialist in endocrinology and nutrition at Badajoz University Hospital in Spain, told Univadis Spain.

The study enrolled adolescent and adult men and women with type 1 diabetes who had not previously been treated with AHCL. After analysis of the results, the specialists concluded that the two AHCLs provide a significant improvement in glucose control. Neither AHCL was superior. Interestingly, the improvement in diabetes-related anxiety was the greatest in Control-IQ users. But there were no differences in improvement in sleep quality.

Beato, the lead study author, said that “there have been other previous analyses, but none with a prospective joint assessment with the same design. Our results demonstrate that both systems are highly effective, reduce glycosylated hemoglobin, and improve all quality-of -life parameters evaluated. The results are comparable as different health centers took part. All experts taking part belong to the Spanish Diabetes Society’s applied technology in diabetes task force. The choice of which AHCL to use will depend on the specialists and availability at each site. User preferences should also be considered as the devices may have individual features making one or the other more convenient for a given individual. But based on our data, there is no clinical indication to choose one over the other.” 

The concept of the two systems analyzed is the same: They both have a glucose sensor that is constantly taking measurements, and both send the information in real time to the system algorithms that decide how much insulin should be supplied, thereby controlling glucose highs and lows. They differ in the design of the system components and in the engineering of the algorithms. But the important thing is that the information for managing an individual’s diabetes and the amount of insulin they need is obtained from the patient himself or herself. Making the systems automated addresses and corrects glucose variability itself even within a single day, as multiple factors such as food, nerves, or sports can affect glucose levels.

“Initial training and support are needed in the event of an incident or problem, but it does not necessarily require more consultation time as they are automated systems and are capable of automatically resolving glucose spikes that may occur in an individual. This may even involve less consultation time. Naturally, patients must continue to be monitored by endocrinology with some regularity,” said Beato. 

These technologies are endorsed by international scientific societies that are seeing more and more advantages of such devices. The societies therefore recommend that closed-loop hybrid systems be the standard of care in people with type 1 diabetes as they are more effective than conventional multidose insulin therapy. They have been recommended by the American Diabetes Association since 2022 and the National Institute for Health and Care Excellence guidelines since January 2023, among others.

Beato regrets that the use of these devices is not widespread in Spain. “We don’t have data about the percentage of people using them, but we get the impression that this number is low and not enough. We need a boost and to break down some barriers such as cost. The devices will ultimately reduce the cost of diabetes control as they are designed to provide better glucose control. They will reduce admissions for complications such as diabetic retinopathy or hypoglycaemia. They will also reduce absence from school and work. In the future, I’m sure the systems will be smaller, which will suit users better.”

This article was translated from Univadis Spain, which is part of the Medscape Professional Network.



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Neutrophil Lymphocyte Ratio as a Predictor of Stroke Severity in Type 2 Diabetes Mellitus: A Single-Center Study

Diabetes News






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Comparative Study of Semaglutide and Dapagliflozin in Type 2 Diabetes Management

Diabetes News
Exploring the Efficacy of Semaglutide and Dapagliflozin in Type 2 Diabetes Treatment: A Leap Towards Precision Medicine


A Comparative Study of Semaglutide and Dapagliflozin

Recent advances in the field of diabetes treatment have led to a trial comparing the efficacy of two antidiabetic drugs: semaglutide and dapagliflozin. The randomized open-label trial, published in Nature, aimed to understand their effects on patients with type 2 diabetes, particularly those with severe insulin-deficient diabetes (SIDD) or severe insulin-resistant diabetes (SIRD). The study discovered that semaglutide induced a larger reduction in glycated haemoglobin (HbA1c) levels than dapagliflozin, especially in those with SIDD.

Identifying Treatment Response through Continuous Pathophysiological Variables

Interestingly, the study found no significant interaction between the drug assignment and the SIDD or SIRD subgroup. Instead, continuous pathophysiological variables such as baseline HbA1c and insulin secretion were more informative in predicting treatment response. These variables, along with body mass index, blood pressure, and insulin resistance measures, were useful in identifying patients likely to benefit most in terms of glycaemic control and cardiovascular risk factors by adding semagliflozin or dapagliflozin.

Combination Therapy: A New Approach in Type 2 Diabetes Management

Further research in Pharmacological Research evaluated the impact of combining dapagliflozin and oral semaglutide in type 2 diabetes patients. This combination therapy outperformed dapagliflozin alone by reducing glycated hemoglobin by 1.2% while improving body mass index, blood pressure, cholesterol, and glucose levels. The combination achieved 55% glycated hemoglobin near-normalization, suggesting it may induce type 2 diabetes pharmacological remission in over 50% of patients.

Implications for Clinical Practices

A related study on the combination therapy of dapagliflozin and semaglutide in PRECARE2 noted its superior efficacy in managing type 2 diabetes. The more significant reduction in HbA1c levels with the combination therapy suggests a promising approach to type 2 diabetes management, potentially changing clinical practices. This therapy offers an effective avenue for managing type 2 diabetes by significantly reducing blood sugar levels and improving other health indicators.

Cardiovascular Disease Prevention and Type 2 Diabetes Treatment

A population-based cohort study in JAMA Network Open investigated the outcomes of SGLT 2i and GLP 1RA therapy among patients with type 2 diabetes, varied by the presence or absence of NAFLD. The study found that both therapies were associated with a reduced risk of major adverse cardiovascular events in patients with type 2 diabetes, regardless of NAFLD status. Specifically, SGLT 2i therapy was associated with a reduced risk of hospitalization for heart failure, supporting current guidelines that recommend GLP 1RA as the first line of therapy for patients with type 2 diabetes and NAFLD.

Stepping Towards Precision Medicine in Diabetes

The findings of these trials highlight the potential for personalized treatment in diabetes, providing valuable insights for future clinical and scientific work in precision medicine. Continuous pathophysiological variables could be more informative in predicting treatment response than stratified subgroups, suggesting a need for a more nuanced approach in diabetes treatment. As our understanding of the disease deepens, we move closer to a future where each patient’s treatment can be tailored according to their unique physiology, bringing us one step closer to the reality of precision medicine in diabetes care.



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5 Easy Ways To Stay Healthy And Manage Diabetes Effectively

Diabetes News


Diabetes is a chronic health condition characterised by elevated levels of blood sugar, either due to insufficient insulin production or the body’s inability to effectively use insulin. This widespread and growing health concern significantly impacts people globally. It not only affects individuals physically but also poses substantial challenges to their overall well-being. The consequences of diabetes are far-reaching, leading to complications such as cardiovascular disease, kidney problems, nerve damage, and vision impairment. Moreover, managing diabetes often requires significant lifestyle changes, including dietary modifications, regular exercise, and, in many cases, medication or insulin therapy.

By promoting healthier lifestyles and enhancing awareness, there is an opportunity to mitigate the effects of diabetes and improve the quality of life for those affected by this prevalent condition. Here are a few ways on how we can effectively manage diabetes and lead a healthy lifestyle:

  1. Know Your Risk
    Understanding your risk factors for diabetes is crucial. Factors such as family history, age, and ethnicity play a role. Regular check-ups, including blood glucose monitoring, can help identify potential risks early, enabling you to take preventive measures.
  2. Healthy Eating
    Adopting a balanced and nutritious diet is a cornerstone of diabetes prevention and management. Focus on whole grains, lean proteins, fruits, and vegetables. Limit the intake of sugary foods, saturated fats, and processed items. Monitoring portion sizes is also essential.
  3. Stay Active
    Regular physical activity is a powerful tool in preventing and managing diabetes. Engage in at least 150 minutes of moderate-intensity exercise per week. Activities such as brisk walking, cycling, or swimming contribute to improved insulin sensitivity and overall health.
  4. Regular Check-ups
    Routine medical check-ups, including comprehensive blood tests and assessments, are essential for monitoring blood glucose levels and overall health. Collaborate closely with healthcare providers to develop a personalised management plan.
  5. Manage Stress
    Chronic stress can impact blood sugar levels. Incorporate stress-reducing techniques such as mindfulness, meditation, or yoga into your routine. Adequate sleep and relaxation are integral components of stress management.
    By incorporating these comprehensive measures into your lifestyle, you can take a proactive approach to prevent diabetes and effectively manage the condition if diagnosed.

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    The 10 biggest diabetes tech stories from 2023

    Diabetes News
    2023 biggest diabetes technology stories


    2023 biggest diabetes technology stories
    Medtronic, EOFlow, Dexcom, Beta Bionics and Tandem Diabetes Care all contributed some of the biggest diabetes technology stories of 2023.

    It was another banner year for diabetes technology, with regulatory approvals, product launches and M&A all playing their part.

    Diabetes technology’s impressive 12 months marked a major trend across medtech as a whole, too.

    In 2022, the diabetes space saw plenty of progress from some of its biggest names and this past year proved no different. Big hitters like Dexcom, Abbott, Medtronic, Insulet and more all contributed to some of the biggest stories in 2023. External factors — like popular GLP-1 drugs and big tech names looking to enter the space — also made the cut.

    Here are 10 of the most intriguing diabetes technology stories from the past 12 months.

    Medtronic was set to buy EOFlow — until it wasn’t

    The medtech giant made a big splash in the insulin delivery space when it announced its plan to buy South Korea-based EOFlow.

    EOFlow EOPatch insulin patch
    [Image from the EOFlow website]

    In May, Medtronic struck a $738 million deal to acquire the insulin patch pump maker. EOFlow previously launched its EOPatch insulin delivery system in Korea and Europe. The company submitted the insulin delivery device for U.S. FDA clearance in January. It already had FDA breakthrough device designation on a wearable, integrated artificial pancreas as well. The disposable device features a glucose monitoring sensor, insulin pump and automated insulin delivery algorithm.

    The deal looked set to rival Medtronic with Insulet and other newer entry to the patch pump space in Tandem Diabetes Care. However, in a surprising turn of events, the deal completely collapsed.

    Based upon “multiple breaches,” the company notified EOFlow of its decision to terminate the deal earlier this month. Medtronic offered a statement saying that it still intended to bring a patch pump to the market and could have one in its product pipeline. EOFlow officials also later expressed their belief in the possibility of resurrecting the deal.

    It’s possible that the story between the two companies remains unfinished.

    Dexcom commences long-awaited G7 launch

    The FDA clearance of the Dexcom G7 continuous glucose monitor was one of the major headlines of 2022. Its launch marked one of the biggest stories of 2023.

    Dexcom G7 CGM Super Bowl Commercial Nick Jonas
    Nick Jonas holds the next-generation G7 CGM. [Image courtesy of Dexcom]

    In February, the company unveiled a Super Bowl commercial announcing the G7’s U.S. launch with musician Nick Jonas. Days later, as the launch commenced, the company also shared that Medicare offers coverage for its beneficiaries using the next-generation CGM.

    “When we set out to design G7, our goal was simple: to make the most accurate, easy-to-use CGM available for as many people with diabetes as possible,” said Kevin Sayer, chair, president and CEO of Dexcom. “The approval of Medicare coverage for G7 helps us deliver on that promise.

    G7 continued to generate buzz throughout the year, particularly this month. On Dec. 6, Tandem Diabetes Care announced that it launched its updated t:slim X2 insulin pump software with the G7. The integration made Tandem the first to offer automated insulin delivery with the latest-generation CGM.

    Just one day later, Beta Bionics became the second to do so, integrating G7 with its iLet bionic pancreas.

    Tandem Diabetes Care enters the patch pump fray

    As one of the big names in automated insulin delivery already, Tandem Diabetes Care took its portfolio a step further this year.

    Tandem Mobi Insulin Pump with App
    The Mobi automated insulin pump with the accompanying mobile app. [Image courtesy of Tandem Diabetes Care]

    In July, the company picked up FDA clearance for its Mobi durable automated insulin delivery system. Tandem says Mobi, which is fully controllable from a mobile app, is the world’s smallest durable AID system.

    Mobi can fit in a coin pocket, clip to clothing or go on the body with an adhesive sleeve. It also features Tandem’s Control-IQ technology for automated insulin delivery. Tandem said in July that it expects a full launch of the system in early 2024.

    Shortly after receiving clearance, Tandem also kicked off a program that provided new and renewing, eligible users of its insulin pump a pathway to its new offerings. Users of the t:slim X2 insulin pump in the U.S. can use the program to move toward owning a Tandem Mobi system.

    Abbott and Insulet progress on technology integration

    With Dexcom making strides in automated insulin integration, it’s no surprise that its main competitor in the CGM space, Abbott, is doing the same.

    Insulet, a leader in insulin patch pump technology, is playing its part in that. The company said in June that it progressed in terms of giving Omnipod 5 — its latest automated insulin delivery system — users a choice over the sensor that accompanies their pump.

    Currently, Omnipod 5 works in conjunction with the Dexcom G6 continuous glucose monitor (CGM). Insulet said it expects to soon begin enrollment for a clinical study integrating Omnipod 5 with the Abbott FreeStyle Libre 2 sensor.

    This study aims to recruit up to 200 participants with type 1 diabetes, both in the adult and pediatric age groups. It spans the UK, France and Belgium. Insulet said it hopes to demonstrate superior efficacy with Omnipod 5 compared to multiple daily injections.

    Medtronic finally picks up approval for the MiniMed 780G

    While Medtronic’s attempt to get into the patch pump market fell short of the finish line, the company still had some major wins in insulin delivery this year — namely with FDA approval granted to the next-generation MiniMed 780G automated insulin delivery system with the Guardian 4 sensor.

    The FDA approved the device in April and U.S. shipments began in June. It was a long road to get to that point, with analysts suggesting at one point that Medtronic’s Diabetes unit was on the spinoff block. Shortly after picking up approval, the company also fully resolved a longstanding warning letter with the FDA.

    In July, the company said that Medicare also covers the MiniMed 780G for all eligible beneficiaries.

    Elsewhere, the company’s other insulin delivery offerings progressed, too. Medtronic received CE mark approval for its new Simplera CGM with InPen smart insulin pen integration in September. The all-in-one, disposable CGM seamlessly integrates with the InPen for real-time, personalized dosing guidance to simplify diabetes management.

    GLP-1 impact

    The GLP-1 drug class has become a major talking point in medtech over the past year and more. This class includes now-household names like Ozempic and Wegovy. The therapeutic class, a glucagon-like peptide 1, has proven to lead to improved blood sugar control and weight loss.

    In addition to the popular therapeutics, some companies — like i20 Therapeutics and Vivani Medical — are developing long-term implants that elute GLP-1s.

    The question has been asked across medtech and diabetes is no different, especially given that some of these drugs are prescribed to treat the condition — what will be the real impact of GLP-1s? According to some of the biggest names in diabetes, there’s no cause for concern.

    BTIG analysts hosted a call with Dr. Osama Hamdy of the Obesity Clinical Program at the Joslin Diabetes Center to discuss the GLP-1 impact. Hamdy, an Associate Professor of Medicine at Harvard Medical School, sees a minor impact on insulin pumps and a potential boom for CGMs.

    An Abbott-sponsored study backed up Hamdy’s opinions. Data from that showed that GLP-1s could be a potential modest accelerator for its FreeStyle Libre CGM product family.

    Then there’s Embecta, which doesn’t yet have an insulin patch pump on the market but is intending to enter that space for the type 2 diabetes population. CEO Dev Kurdikar also sees a minor impact on that side of the business, plus he points out Embecta’s other delivery devices, like needles and syringes, could be used to deliver GLP-1s.

    Much remains to be seen on the GLP-1 front, but early suggestions should allay any panic in the diabetes device space.

    Beta Bionics wins landmark approval

    Medtronic and Tandem didn’t have the only major regulatory wins for insulin delivery technology this year. Beta Bionics, before the G7 integration this month, picked up FDA approval for its iLet system in May. The initial clearance covered use with the Dexcom G6.

    The Beta Bionics iLet Bionic Pancreas uses an adaptive, closed-loop algorithm. It initializes only with a user’s body weight and requires no additional insulin dosing parameters. The algorithm removes the need to manually adjust insulin pump therapy settings and variables.

    iLet also simplifies mealtime use by replacing conventional carb counting with a new meal announcement feature. This feature enables users to estimate the amount of carbs in their meal as “small,” “medium” or “large.” Over time, the algorithm learns to respond to users’ individual insulin needs.

    Beta Bionics also received support for its commercialization efforts a few months after the approval came through. The company raised $100 million in August.

    Abbott makes a massive diabetes M&A play

    While FreeStyle Libre integration continues to progress, Abbott is making moves in other areas of diabetes management.

    On Sept. 5 the company entered into a definitive agreement to acquire Bigfoot Biomedical. Less than three weeks later, Abbott completed its buy of the smart insulin management company.

    Bigfoot develops the Bigfoot Unity smart insulin management system. The FDA-cleared platform simplifies continuous glucose monitors (CGMs) and the data they produce. The system works exclusively with Abbott’s FreeStyle Libre CGM technology.

    It features a smart insulin pen cap, which takes data from a CGM and informs the patient exactly how much insulin they need. Bigfoot Unity also includes a customer smartphone app connected to a cloud-based online portal used by healthcare providers to support patients. The system works with the FreeStyle Libre 2 sensors and all major brands of disposable insulin pens offered in the U.S.

    Analysts said they weren’t surprised by the deal and view the strategic tuck-in “favorably,” saying it could accelerate Bigfoot Unity’s adoption for multiple daily injection (MDI) diabetes patients.

    Will Apple make its mark in glucose monitoring?

    The big names in diabetes plugged along in 2023, but they also received some potential new competition.

    Blooomberg reported in April that tech giant Apple has a “moonshot-style” project in the works. According to “sources familiar with the matter,” Apple wants to shake up the CGM market with non-invasive glucose monitoring through the Apple Watch. Bloomberg says the company still has years ahead in this development of the technology, which wouldn’t penetrate the skin.

    According to the report, Apple’s project goes back more than 12 years. The company tested the glucose technology on “hundreds of people,” Bloomberg said. That includes human trials of those who don’t know if they’re diabetic, plus those with prediabetes and type 2 diabetes. These tests compared the technology to fingersticks, the report noted.

    The initial technology, per the report, comes in the form of a prototype device (around the size of an iPhone) strapped to the bicep. Bloomberg says Apple’s overall goal remains to bring this technology to the Apple Watch.

    This also makes CGM an interesting area to watch for potential patent litigation, given Apple’s recent struggles with medical applications for its technology. Both Masimo and AliveCor recently picked up huge victories over the tech giant around medical monitoring technology.

    11 diabetes startups you need to know

    Between established players and relative newcomers to diabetes technology, plenty of news crossed the airwaves this year. But plenty of companies in their infancy can still make a big difference.

    A few noteworthy examples include Diatech Diabetes and its SmartFusion infusion monitoring software. It detects insulin delivery failure and offers insights on how infusion performance affects diabetes management.

    Delaware-based Medtech Concept develops a range of medical products for people with diabetes. Its diabetes management system combines digital health software with a market-tested, miniature therapeutic delivery device. The company aims to provide real improvements in the control of diabetes.

    Orange Biomed develops its flagship OBM rapid A1c. This platform helps people manage their diabetes through HbA1c testing. The company believes that, despite HbA1c testing’s importance, there remains a lack of at-home monitoring for diabetic patients that offers the accuracy and precision of laboratory devices.

    Keep an eye out for these companies and many more as they look to make their mark in the diabetes market.



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