Tag Archives: complications

Diabetes complications worsen prognosis for colorectal cancer patients

Diabetes News

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Complications of diabetes can have numerous negative health effects, from impaired vision and nerve damage to kidney dysfunction and heart disease. In an analysis of information on adults with colorectal cancer, patients who also had diabetes—particularly those with diabetic complications—faced a higher risk of dying early. The results are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.

For the study, Kuo‐Liong Chien, MD, PhD, of National Taiwan University, and his colleagues examined data registered between 2007 and 2015 in the Taiwan Cancer Registry Database, which is linked to health insurance and death records. Their analysis included 59,202 individuals with stage I–III colorectal cancer who underwent potentially curative surgery to remove their tumors. Among these patients, 9,448 experienced a cancer recurrence and 21,031 died from any cause during the study period.

Compared with individuals without diabetes, those with uncomplicated diabetes were at a minimally or insignificantly higher risk of all‐cause and cancer‐specific death, whereas those with complicated diabetes had 85% higher odds of death from any cause and 41% higher odds of death from cancer. These associations were more pronounced in women and in patients with early‐stage colorectal cancer.

Also, compared to patients without diabetes, patients with uncomplicated or complicated diabetes had a 10–11% higher risk of colorectal cancer recurrence.

The mechanisms behind the relationship between diabetic severity and poor colorectal cancer prognosis could involve various pathways and responses triggered by high insulin and glucose levels in the blood, as well as elevated inflammatory states, which are characteristic of type 2 diabetes.

While a higher diabetes prevalence was noted in patients with colorectal cancer, the study suggests that coordinated medical care involving multiple specialists can help prevent diabetes complications, potentially improving long-term colorectal cancer oncological outcomes, particularly in women and patients with early-stage cancer.”

Kuo‐Liong Chien, MD, PhD, National Taiwan University

Source:

Journal reference:

Hsu, H. Y., et al. (2023) Diabetic severity and oncological outcomes of colorectal cancer following curative resection: A population-based cohort study in Taiwan diabetes and colorectal cancer prognosis. Cancer. doi.org/10.1002/cncr.34975.

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Complications with Diabetes

Management

Just like in any other illnesses, the first thing that people need is to be informed and educated about the disease that may be prone to. In case of diabetes, extensive knowledge about this can help people who are already suffering from it to cope up and manage and can also help those who don’t have it yet to be more careful and to avoid the illness.

But, aside from having extensive knowledge on the disease such as its causes, symptoms, diagnosis and treatment, it also pays to know if there would be related complications. This is to prepare one’s self emotionally, physically, and emotionally about the possibilities of coping not just with diabetes but other complications related to it as well.

There are certain factors that affect people to be prone to diabetes such as age, heredity and ethnicity. But regardless of the risk factors, the related complications would just be the same. The following are just some of the complications of diabetes that people who are prone to it must pay attention to:

1. HEART DISEASE AND STROKE. Experts say that people who have diabetes have greater risks to having coronary heart diseases and to stroke compared to those who don’t have them. In fact, these complications are the lead causes of death among diabetics all over the world. People suffering from diabetes are prone to heart diseases and stroke because the fatty deposits brought by drastic changes in the body can block the arteries and leads to heart attack. Because of lesser amount of insulin in the body compared to regular people, diabetics have higher incidence of blood clotting and can also lead to high blood pressure or hypertension.

2. DIABETIC KIDNEY DISEASE. Among people with diabetes, kidney failure is the most common complication because the blood-filtering units of the kidneys are being damaged. Once the kidney has been damaged, important proteins are being along with urine and eventually, the kidneys won’t be able to remove the waste products present in the blood anymore. The good thing is, not all diabetics experience End-Stage Kidney Disease (ESRD) which can be life threatening. To avoid this complication, you must stop smoking cigarettes and always keep the blood pressure under control at all times.

3. DIABETIC EYE DISEASE. This refers to the group of eye problems that diabetics”people with diabetes” may have as a result of the chronic disease. In worst cases, this set of eye related problems such as diabetic retinopathy, damaged vessels of the eye’s retina, cataract, cloudiness in the lens of the eyes, glaucoma, and increased fluid pressure inside the eye that is damaging to optic nerve. All of these, when not treated immediately and now monitored properly can lead to total loss of vision loss or blindness.

4. DIABETIC NEUROPATHY. Those people who are into smoking, drinking, and those who have poor control with glucose are more prone to developing neuropathy compared to those diabetics who are not into these vices and bad habits.

5. GASTROPARESIS. This disorder involves the stomach as a result of prolonged emptying. Studies show that around 20 to 30 percent of diabetics suffering from “type 1 diabetes” are more prone to this diabetes complication because it severely damages the “vagus nerve” which is responsible for keeping the food moving through person’s the digestive tract. Although it is also diagnosed among those who have “type 2 diabetes” the cases are comparatively lower.